Rome to Palermo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 9 daily rides to get from Rome to Palermo. Trains leave from Roma Termini and arrive at Palermo Centrale every about 1 hour on average. The trip by train from Rome to Palermo last on average 11:15 travelling with high-speed trains (Frecciarossa or Italotreno) If travelling with Trenitalia, you need to know the Rome to Palermo train schedule: the first train leaves at 07:35, while the last ride is at 22:26. A Rome to Palermo train cost about 39.90 €. But how long is the train ride from Rome to Palermo? Your journey takes about 12 hours on average. Trenitalia offers 2 direct trains between these two cities. Thanks to Trenitalia offers, you can save on your trip from Rome to Palermo and find prices starting from 29 €! If you need to travel this week, prices range from 69.90 € to 80.50€. Booking your train ticket a few weeks in advance though, you can find low cost trains from Rome to Palermo with fares starting from 24.90€, saving 71% on average.