Rome to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Roma Termini and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Rome to Syracuse train schedule: the first train leaves at 07:35, while the last ride is at 22:26. A Rome to Syracuse train cost about 44.90 €. But how long is the train ride from Rome to Syracuse? Your journey takes about 11 hours on average. Trenitalia offers 2 direct trains between these two cities. Thanks to Trenitalia, offers, you can save on your trip from Rome to Syracuse and find low cost tickets starting from 38 €! If you need to travel this week, prices range from 59.90 € to 77.50€. Booking your train ticket a few weeks in advance though, you can find low cost trains from Rome to Syracuse with fares starting from 39.90€, saving 44% on average.