To get from Rome to Syracuse by train you can catch one of the 7 trains that everyday travel between these two cities. The first train to Syracuse leaves from Rome at 07:26 and the last train departs at 22:26. The trip by train from Rome to Syracuse last on average 10:54 travelling with high-speed trains (Frecciarossa or Italotreno) If you choose a local train the trip lasts on average 11:03 hours. For your trip from Rome to Syracuse by train you can choose to leave from one of Rome main stations: Roma Termini Prices for next month range from € 39 to € 79. The most economic train is Intercity () that departs at 07:26 and arrives in Syracuse at 18:29 at € 39. On Wanderio you can compare all schedules, fares and railway companies to Syracuse and book the best itinerary starting from Rome.