San Donato Milanese to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Borgo Lombardo and arrive at Niscemi every about 4 hours on average. If travelling with Trenitalia, you need to know the San Donato Milanese to Niscemi train schedule: the first train leaves at 18:16, while the last ride is at 22:13. A San Donato Milanese to Niscemi train cost about 112.75 €. But how long is the train ride from San Donato Milanese to Niscemi? Your journey takes about 16 hours on average.