San Donato Milanese to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from S. Giuliano Milanese, Milano Rogoredo, Salerno and arrive at Palermo Centrale every 60 minutes on average. If travelling with Trenitalia, you need to know the San Donato Milanese to Palermo train schedule: the first train leaves at 08:35, while the last ride is at 22:32. A San Donato Milanese to Palermo train cost about 131.4 €. But how long is the train ride from San Donato Milanese to Palermo? Your journey takes about 16 hours on average. If you need to travel this week, prices start from 59.00€. When booking your train ticket a few weeks in advance though, you can find low cost trains from San Donato Milanese to Palermo with fares starting from 29.90€, saving up to 49%.