San Donato Milanese to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Borgo Lombardo and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the San Donato Milanese to Syracuse train schedule: the first train leaves at 07:46, while the last ride is at 22:13. A San Donato Milanese to Syracuse train cost about 114.0 €. But how long is the train ride from San Donato Milanese to Syracuse? Your journey takes about 18 hours on average.