San Nicola la Strada to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Caserta and arrive at Palermo Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the San Nicola la Strada to Palermo train schedule: the first train leaves at 09:20, while the last ride is at 21:41. A San Nicola la Strada to Palermo train cost about 60.7 €. But how long is the train ride from San Nicola la Strada to Palermo? Your journey takes about 11 hours on average.