San Sebastiano to Palermo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 7 daily rides to get from San Sebastiano to Palermo. The first train to Palermo leaves from San Sebastiano at 13:54 and the last train departs at 22:35. If you choose a local train the trip lasts on average 17:17 hours. For your trip from San Sebastiano to Palermo by train you can choose to leave from one of San Sebastiano main stations: Brescia On Wanderio you can compare all schedules, fares and railway companies to Palermo and book the best itinerary starting from San Sebastiano.