San Severo to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from S. Severo and arrive at Siracusa every about 4 hours on average. If travelling with Trenitalia, you need to know the San Severo to Syracuse train schedule: the first train leaves at 04:59, while the last ride is at 04:59. A San Severo to Syracuse train cost about 81.5 €. But how long is the train ride from San Severo to Syracuse? Your journey takes about 18 hours on average.