Sant'Anastasia to Acireale trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Napoli Centrale and arrive at Acireale every about 3 hours on average. If travelling with Trenitalia, you need to know the Sant'Anastasia to Acireale train schedule: the first train leaves at 21:42, while the last ride is at 23:53. A Sant'Anastasia to Acireale train cost about 49.0 €. But how long is the train ride from Sant'Anastasia to Acireale? Your journey takes about 10 hours on average. Trenitalia offers 1 direct trains between these two cities.