Sant'Anastasia to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalnuovo di Napoli, Reggio di Calabria Centrale and arrive at Comiso every about 4 hours on average. If travelling with Trenitalia, you need to know the Sant'Anastasia to Comiso train schedule: the first train leaves at 08:56, while the last ride is at 13:19. A Sant'Anastasia to Comiso train cost about 28.05 €. But how long is the train ride from Sant'Anastasia to Comiso? Your journey takes about 12 hours on average.