Sant'Anastasia to Marsala trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalnuovo di Napoli and arrive at Spagnuola every about 12 hours on average. If travelling with Trenitalia, you need to know the Sant'Anastasia to Marsala train schedule: the first train leaves at 21:21, while the last ride is at 21:21. A Sant'Anastasia to Marsala train cost about 97.3 €. But how long is the train ride from Sant'Anastasia to Marsala? Your journey takes about 17 hours on average.