Sant'Anastasia to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Napoli Centrale, Casalnuovo di Napoli and arrive at Villa S. Giovanni, Messina Centrale, Reggio di Calabria Centrale every 60 minutes on average. If travelling with Trenitalia, you need to know the Sant'Anastasia to Messina train schedule: the first train leaves at 15:55, while the last ride is at 23:53. A Sant'Anastasia to Messina train cost about 44.90 €. But how long is the train ride from Sant'Anastasia to Messina? Your journey takes about 6 hours on average. Trenitalia offers 2 direct trains between these two cities. If you need to travel this week, prices range from 50.00 € to 75.70€. Booking your train ticket a few weeks in advance though, you can find low cost trains from Sant'Anastasia to Messina with fares starting from 12.90€, saving 75% on average.