Sant'Anastasia to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalnuovo di Napoli, Reggio di Calabria Centrale and arrive at Niscemi every about 2 hours on average. If travelling with Trenitalia, you need to know the Sant'Anastasia to Niscemi train schedule: the first train leaves at 08:56, while the last ride is at 13:19. A Sant'Anastasia to Niscemi train cost about 26.25 €. But how long is the train ride from Sant'Anastasia to Niscemi? Your journey takes about 9 hours on average.