Sant'Anastasia to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalnuovo di Napoli and arrive at Palermo Notarbartolo every about 12 hours on average. If travelling with Trenitalia, you need to know the Sant'Anastasia to Palermo train schedule: the first train leaves at 08:56, while the last ride is at 08:56. A Sant'Anastasia to Palermo train cost about 66.8 €. But how long is the train ride from Sant'Anastasia to Palermo? Your journey takes about 10 hours on average.