Sant'Anastasia to Ragusa trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Reggio di Calabria Centrale, Casalnuovo di Napoli and arrive at Ragusa every about 6 hours on average. If travelling with Trenitalia, you need to know the Sant'Anastasia to Ragusa train schedule: the first train leaves at 13:19, while the last ride is at 21:21. A Sant'Anastasia to Ragusa train cost about 29.6 €. But how long is the train ride from Sant'Anastasia to Ragusa? Your journey takes about 12 hours on average.