Sant'Anastasia to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Casalnuovo di Napoli, Reggio di Calabria Centrale and arrive at Siracusa every about 4 hours on average. If travelling with Trenitalia, you need to know the Sant'Anastasia to Syracuse train schedule: the first train leaves at 09:20, while the last ride is at 21:21. A Sant'Anastasia to Syracuse train cost about 24.3 €. But how long is the train ride from Sant'Anastasia to Syracuse? Your journey takes about 10 hours on average.