Sant'Antimo to Messina trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from S. Antimo-S. Arpino and arrive at Messina Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Sant'Antimo to Messina train schedule: the first train leaves at 08:37, while the last ride is at 22:07. A Sant'Antimo to Messina train cost about 50.0 €. But how long is the train ride from Sant'Antimo to Messina? Your journey takes about 8 hours on average.