Sant'Antimo to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from S. Antimo-S. Arpino, Reggio di Calabria Centrale and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Sant'Antimo to Syracuse train schedule: the first train leaves at 08:37, while the last ride is at 22:07. A Sant'Antimo to Syracuse train cost about 24.3 €. But how long is the train ride from Sant'Antimo to Syracuse? Your journey takes about 10 hours on average.