Santeramo in Colle to Comiso trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Santeramo and arrive at Comiso every about 12 hours on average. If travelling with Trenitalia, you need to know the Santeramo in Colle to Comiso train schedule: the first train leaves at 22:57, while the last ride is at 22:57. A Santeramo in Colle to Comiso train cost about 60.55 €. But how long is the train ride from Santeramo in Colle to Comiso? Your journey takes 1 day on average.