Sassuolo to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Sassuolo to Niscemi. Trains leave from Rubiera and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Sassuolo to Niscemi train schedule: the first train leaves at 17:23, while the last ride is at 17:23. A Sassuolo to Niscemi train cost about 265.45 €. But how long is the train ride from Sassuolo to Niscemi? Your journey takes about 23 hours on average.