Sassuolo to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Rubiera and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Sassuolo to Palermo train schedule: the first train leaves at 09:23, while the last ride is at 21:26. A Sassuolo to Palermo train cost about 106.3 €. But how long is the train ride from Sassuolo to Palermo? Your journey takes about 16 hours on average.