Segrate to Caltanissetta trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Segrate and arrive at Caltanissetta Centrale every about 3 hours on average. If travelling with Trenitalia, you need to know the Segrate to Caltanissetta train schedule: the first train leaves at 14:14, while the last ride is at 19:29. A Segrate to Caltanissetta train cost about 113.4 €. But how long is the train ride from Segrate to Caltanissetta? Your journey takes about 21 hours on average.