Segrate to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Segrate and arrive at Milazzo every about 3 hours on average. If travelling with Trenitalia, you need to know the Segrate to Milazzo train schedule: the first train leaves at 07:44, while the last ride is at 21:30. A Segrate to Milazzo train cost about 63.8 €. But how long is the train ride from Segrate to Milazzo? Your journey takes about 16 hours on average.