Segrate to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Segrate to Niscemi. Trains leave from Segrate and arrive at Niscemi every about 6 hours on average. If travelling with Trenitalia, you need to know the Segrate to Niscemi train schedule: the first train leaves at 17:59, while the last ride is at 19:29. A Segrate to Niscemi train cost about 113.05 €. But how long is the train ride from Segrate to Niscemi? Your journey takes about 13 hours on average.