Segrate to Noto trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Segrate and arrive at Noto every about 3 hours on average. If travelling with Trenitalia, you need to know the Segrate to Noto train schedule: the first train leaves at 14:14, while the last ride is at 19:29. A Segrate to Noto train cost about 111.25 €. But how long is the train ride from Segrate to Noto? Your journey takes about 20 hours on average.