Segrate to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Segrate and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Segrate to Syracuse train schedule: the first train leaves at 07:59, while the last ride is at 21:30. A Segrate to Syracuse train cost about 115.2 €. But how long is the train ride from Segrate to Syracuse? Your journey takes about 17 hours on average.