Senigallia to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Senigallia and arrive at Milazzo every about 1 hour on average. If travelling with Trenitalia, you need to know the Senigallia to Milazzo train schedule: the first train leaves at 07:21, while the last ride is at 22:56. A Senigallia to Milazzo train cost about 79.65 €. But how long is the train ride from Senigallia to Milazzo? Your journey takes about 17 hours on average.