Senigallia to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Senigallia and arrive at Niscemi every about 2 hours on average. If travelling with Trenitalia, you need to know the Senigallia to Niscemi train schedule: the first train leaves at 13:31, while the last ride is at 21:02. A Senigallia to Niscemi train cost about 90.8 €. But how long is the train ride from Senigallia to Niscemi? Your journey takes about 6 hours on average.