Senigallia to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Senigallia and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Senigallia to Syracuse train schedule: the first train leaves at 07:21, while the last ride is at 21:02. A Senigallia to Syracuse train cost about 111.25 €. But how long is the train ride from Senigallia to Syracuse? Your journey takes about 17 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Senigallia to Syracuse and find low cost tickets starting from 86 €!