Seregno to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Seregno and arrive at Castelvetrano every about 4 hours on average. If travelling with Trenitalia, you need to know the Seregno to Castelvetrano train schedule: the first train leaves at 17:30, while the last ride is at 19:30. A Seregno to Castelvetrano train cost about 82.45 €. But how long is the train ride from Seregno to Castelvetrano? Your journey takes about 10 hours on average.