Seregno to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Seregno and arrive at Palermo Notarbartolo every about 2 hours on average. If travelling with Trenitalia, you need to know the Seregno to Palermo train schedule: the first train leaves at 13:30, while the last ride is at 19:30. A Seregno to Palermo train cost about 110.5 €. But how long is the train ride from Seregno to Palermo? Your journey takes about 20 hours on average.