Seregno to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Seregno and arrive at Siracusa every about 2 hours on average. If travelling with Trenitalia, you need to know the Seregno to Syracuse train schedule: the first train leaves at 07:30, while the last ride is at 19:30. A Seregno to Syracuse train cost about 108.8 €. But how long is the train ride from Seregno to Syracuse? Your journey takes about 18 hours on average.