Sesto San Giovanni to Caltagirone trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sesto S. Giovanni and arrive at Caltagirone every about 2 hours on average. If travelling with Trenitalia, you need to know the Sesto San Giovanni to Caltagirone train schedule: the first train leaves at 07:48, while the last ride is at 19:27. A Sesto San Giovanni to Caltagirone train cost about 112.4 €. But how long is the train ride from Sesto San Giovanni to Caltagirone? Your journey takes about 16 hours on average.