Sesto San Giovanni to Enna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sesto S. Giovanni and arrive at Enna every about 6 hours on average. If travelling with Trenitalia, you need to know the Sesto San Giovanni to Enna train schedule: the first train leaves at 18:13, while the last ride is at 18:13. A Sesto San Giovanni to Enna train cost about 226.85 €. But how long is the train ride from Sesto San Giovanni to Enna? Your journey takes about 17 hours on average.