Sesto San Giovanni to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sesto S. Giovanni and arrive at Niscemi every about 3 hours on average. If travelling with Trenitalia, you need to know the Sesto San Giovanni to Niscemi train schedule: the first train leaves at 18:13, while the last ride is at 18:13. A Sesto San Giovanni to Niscemi train cost about 113.05 €. But how long is the train ride from Sesto San Giovanni to Niscemi? Your journey takes about 23 hours on average.