Sesto San Giovanni to Noto trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sesto S. Giovanni and arrive at Noto every 60 minutes on average. If travelling with Trenitalia, you need to know the Sesto San Giovanni to Noto train schedule: the first train leaves at 07:48, while the last ride is at 19:27. A Sesto San Giovanni to Noto train cost about 111.25 €. But how long is the train ride from Sesto San Giovanni to Noto? Your journey takes about 20 hours on average.