Sezze to Castelvetrano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sezze Romano and arrive at Castelvetrano every about 6 hours on average. If travelling with Trenitalia, you need to know the Sezze to Castelvetrano train schedule: the first train leaves at 07:25, while the last ride is at 21:39. A Sezze to Castelvetrano train cost about 81.85 €. But how long is the train ride from Sezze to Castelvetrano? Your journey takes about 15 hours on average.