Sezze to Marsala trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sezze Romano and arrive at Spagnuola every about 6 hours on average. If travelling with Trenitalia, you need to know the Sezze to Marsala train schedule: the first train leaves at 21:39, while the last ride is at 22:37. A Sezze to Marsala train cost about 71.1 €. But how long is the train ride from Sezze to Marsala? Your journey takes about 19 hours on average.