Sezze to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sezze Romano and arrive at Milazzo every about 3 hours on average. If travelling with Trenitalia, you need to know the Sezze to Milazzo train schedule: the first train leaves at 07:25, while the last ride is at 22:37. A Sezze to Milazzo train cost about 57.1 €. But how long is the train ride from Sezze to Milazzo? Your journey takes about 9 hours on average.