Sezze to Palermo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sezze Romano and arrive at Palermo Centrale every about 2 hours on average. If travelling with Trenitalia, you need to know the Sezze to Palermo train schedule: the first train leaves at 07:25, while the last ride is at 22:35. A Sezze to Palermo train cost about 50.1 €. But how long is the train ride from Sezze to Palermo? Your journey takes about 12 hours on average.