Sezze to Syracuse trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Sezze Romano and arrive at Siracusa every about 3 hours on average. If travelling with Trenitalia, you need to know the Sezze to Syracuse train schedule: the first train leaves at 07:25, while the last ride is at 22:37. A Sezze to Syracuse train cost about 60.1 €. But how long is the train ride from Sezze to Syracuse? Your journey takes about 11 hours on average.