Sienna to Agrigento trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Agrigento Bassa every about 6 hours on average. If travelling with Trenitalia, you need to know the Sienna to Agrigento train schedule: the first train leaves at 18:43, while the last ride is at 21:26. A Sienna to Agrigento train cost about 106.4 €. But how long is the train ride from Sienna to Agrigento? Your journey takes about 20 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Agrigento and find low cost tickets starting from 67 €!