Sienna to Agrigento trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Sienna to Agrigento. Trains leave from Siena and arrive at Agrigento Bassa every about 6 hours on average. If travelling with Trenitalia, you need to know the Sienna to Agrigento train schedule: the first train leaves at 18:43, while the last ride is at 21:26. A Sienna to Agrigento train cost about 106.4 €. But how long is the train ride from Sienna to Agrigento? Your journey takes about 20 hours on average.