Sienna to Alessandria trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Alessandria every 60 minutes on average. If travelling with Trenitalia, you need to know the Sienna to Alessandria train schedule: the first train leaves at 06:25, while the last ride is at 21:26. A Sienna to Alessandria train cost about 28.2 €. But how long is the train ride from Sienna to Alessandria? Your journey takes about 6 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Alessandria and find low cost tickets starting from 34 €!