Sienna to Alpignano trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Alpignano every 60 minutes on average. If travelling with Trenitalia, you need to know the Sienna to Alpignano train schedule: the first train leaves at 06:36, while the last ride is at 21:26. A Sienna to Alpignano train cost about 58.6 €. But how long is the train ride from Sienna to Alpignano? Your journey takes about 7 hours on average.