To get from Sienna a Casarano by train you can catch one of the 22 trains that everyday travel between Siena and Lecce, the closest station to the city. For your trip from Siena to Lecce by train you can choose to leave from one of Siena main stations: Siena, Salerno If travelling with Trenitalia, you need to know the Siena to Lecce train schedule: the first train leaves at 05:43, while the last ride is at 19:18. A Siena to Lecce train cost about 19.85 €. But how long is the train ride from Siena to Lecce? Your journey takes about 9 hours on average.