Sienna to Catania trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Catania Centrale every about 4 hours on average. If travelling with Trenitalia, you need to know the Sienna to Catania train schedule: the first train leaves at 08:47, while the last ride is at 21:26. A Sienna to Catania train cost about 120.50 €. But how long is the train ride from Sienna to Catania? Your journey takes about 15 hours on average. Thanks to Trenitalia, offers, you can save on your trip from Sienna to Catania and find low cost tickets starting from 90 €! If you need to travel this week, prices start from 124.50€.