Sienna to Comiso trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 2 daily rides to get from Sienna to Comiso. Trains leave from Siena and arrive at Comiso every about 6 hours on average. If travelling with Trenitalia, you need to know the Sienna to Comiso train schedule: the first train leaves at 17:43, while the last ride is at 17:46. A Sienna to Comiso train cost about 159.6 €. But how long is the train ride from Sienna to Comiso? Your journey takes about 19 hours on average.