Sienna to Enna trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Enna every about 6 hours on average. If travelling with Trenitalia, you need to know the Sienna to Enna train schedule: the first train leaves at 18:43, while the last ride is at 21:26. A Sienna to Enna train cost about 85.75 €. But how long is the train ride from Sienna to Enna? Your journey takes about 18 hours on average.