Sienna to Milazzo trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Milazzo every about 2 hours on average. If travelling with Trenitalia, you need to know the Sienna to Milazzo train schedule: the first train leaves at 08:18, while the last ride is at 21:26. A Sienna to Milazzo train cost about 89.2 €. But how long is the train ride from Sienna to Milazzo? Your journey takes about 14 hours on average.