Sienna to Milazzo trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 5 daily rides to get from Sienna to Milazzo. The first train to Milazzo leaves from Sienna at 08:18 and the last train departs at 21:26. If you choose a local train the trip lasts on average 11:57 hours. For your trip from Sienna to Milazzo by train you can choose to leave from one of Sienna main stations: Siena On Wanderio you can compare all schedules, fares and railway companies to Milazzo and book the best itinerary starting from Sienna.