Sienna to Niscemi trains might be a good value for money solution; travelling in Italy by train is often rather cheap and faster than taking a bus indeed. You can count on 1 daily rides to get from Sienna to Niscemi. Trains leave from Siena and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Sienna to Niscemi train schedule: the first train leaves at 18:43, while the last ride is at 18:43. A Sienna to Niscemi train cost about 157.25 €. But how long is the train ride from Sienna to Niscemi? Your journey takes about 22 hours on average.