Sienna to Niscemi trains might be a good value for money solution: travelling in Italy by train is often rather cheap and faster than taking a bus indeed Trains leave from Siena and arrive at Niscemi every about 12 hours on average. If travelling with Trenitalia, you need to know the Sienna to Niscemi train schedule: the first train leaves at 18:43, while the last ride is at 18:43. A Sienna to Niscemi train cost about 157.25 €. But how long is the train ride from Sienna to Niscemi? Your journey takes about 22 hours on average.